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The commercialisation of StemPrintER and its next generation derivative SPARE, the multi-gene prognostic assay intended for the prediction of risk of recurrence in luminal, ER+/HER2- breast cancer patients.

Multigene prognostic tests can assist decision making on treatments, differentiating low risk patients who could be spared chemotherapy from higher risk patients who might benefit from chemotherapy or prolonged endocrine treatments.

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Latest News

Accustem Sciences Limited Announces Plans to List in the U.S.

Accustem Sciences Limited, today announced that it intends to file a listing application with the Nasdaq Stock Market shortly after completion of the distribution of shares in Accustem to Tiziana Life Sciences plc shareholders.

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The board of directors of Accustem has resolved that the Nasdaq listing venue is more appropriate to the nature of Accustem's business.

About Accustem Sciences

StemPrintER is a multi-gene prognostic assay intended to predict the risk of recurrence of R+/HER2- breast cancer, and Spare, a derivative of StemPrintER, combines StemPrintER with two clinical markers. This gives a more refined risk model.

These assays are intended for the prediction of the risk of recurrence of breast cancer, based on the detection of 20 stem cell markers. The assay has been evaluated in an initial retrospective validation study using a consecutive cohort of approximately 2,400 patients with breast cancer. Subsequently, StemPrintER has been further validated in an independent retrospective cohort of more than 800 ER+/HER2- postmenopausal patients from the TransATAC trial.

A poster presented at the American Society of Clinical Oncology (ASCO) Virtual Conference in May 2020, demonstrated the superiority of StemPrintER stem cell based genomic prognostic tool versus the market leader, Oncotype DX, in predicting recurrence in ER+/HER2- postmenopausal breast cancer patients.

Endocrine receptor-positive (ER+) breast cancers make up most breast cancer cases, however display significant variability in clinical behaviour, this makes prognosis and therapy response challenging. Although the overall prognosis of patients is good, a significant proportion of these women will experience distant recurrence in the first 10 years post-surgery.

For patients who also have a negative HER2 status (HER2-) and risk of recurrence, the standard of care is endocrine therapy, with the addition of chemotherapy in patients. However, these parameters are often insufficient to predict risk of recurrence in ER+/HER2- breast cancer patients, and consequently, these patients are either over- or under-treated.

Accustem anticipates this prognostic test to be used in conjunction with clinical evaluation to identify those patients at increased risk for early and/or late metastasis.

For further enquiries:

Accustem Sciences Limited
Gabriele Cerrone
+44 (0)20 7495 2379

Technology

StemPrintER was developed to be a novel genomic predictor based on 20 stem cell genes. These 20 genes have high expression levels that identify a similar group of patients with negative results from four distinct public breast cancer datasets.

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Our Team

Directors

Gabriele Cerrone

Gabriele Cerrone

Dr Kunwar Shailubhai

Dr Kunwar Shailubhai

Will Simon

Willy Simon

John Brancaccio

John Brancaccio

Contact

UK Headquarters

Accustem
55 Park Lane
London W1K 1NA
United Kingdom